Hydrochloric Acid → HCID 13355749, compound

HRID 1111971Notes

Reaction equation

Cl.[NH2:2][C:3]1[C:8]([I:9])=[CH:7][C:6]([C:10](=[O:16])[CH2:11][NH:12][CH:13]([CH3:15])[CH3:14])=[CH:5][C:4]=1[F:17].[BH4-].[Na+]>>[NH2:2][C:3]1[C:8]([I:9])=[CH:7][C:6]([CH:10]([OH:16])[CH2:11][NH:12][CH:13]([CH3:14])[CH3:15])=[CH:5][C:4]=1[F:17]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4311764Sodium borohydride

HCID 22765864HCID 22765864, compound

Product 1

HCID 13355749HCID 13355749, compound

Procedure

m.p. of the hydrochloride: 203°-205° C. (decomp.), was prepared from 4'-amino-3'-fluoro-2-isopropylamino-5'-iodo-acetophenone and sodium borohydride analogous to Example 49.

Sources & evidence

ORD record: ord-6646239ce5874dea94f667d4ffeb4879
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

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