Hydrochloric Acid → 1-(4'-Amino-3',5'-dicyano-phenyl)-2-tert.butylamino-ethanol

HRID 1111996Notes

Reaction equation

Cl.[NH2:2][C:3]1[C:8]([C:9]#[N:10])=[CH:7][C:6]([C:11](=[O:18])[CH2:12][NH:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:5][C:4]=1[C:19]#[N:20]>>[NH2:2][C:3]1[C:4]([C:19]#[N:20])=[CH:5][C:6]([CH:11]([OH:18])[CH2:12][NH:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[CH:7][C:8]=1[C:9]#[N:10]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 13355679HCID 13355679, compound

Product 1

HCID 418501-(4'-Amino-3',5'-dicyano-phenyl)-2-tert.butylamino-ethanol

Procedure

m.p. of the hydrochloride: 251°-253° C. (decomp.), was prepared from 4'-amino-2-tert.butylamino-3',5'-dicyano-acetophenone analogous to Example 48.

Sources & evidence

ORD record: ord-78b4a3ee2fb5452e8d2011ef38adcb05
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

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