Ethanol → HCID 70614840, compound

HRID 1112004Notes

Reaction equation

HRID 1112004 reaction equation
CC([OH:4])C.[CH2:5]([N:12]([CH:17]([CH3:19])[CH3:18])[CH2:13][CH:14]1[O:16][CH2:15]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[Na].[CH3:21][S:22]([C:25]1[C:26](C)=[CH:27]C(O)=[CH:29][CH:30]=1)(=[O:24])=[O:23].[CH2:33](O)[CH3:34]>>[CH2:5]([N:12]([CH:17]([CH3:18])[CH3:19])[CH2:13][CH:14]([OH:4])[CH2:15][O:16][C:30]1[CH:29]=[C:33]([CH3:34])[CH:27]=[CH:26][C:25]=1[S:22]([CH3:21])(=[O:24])=[O:23])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 3776IsopropanolHCID 11030970HCID 11030970, compoundHCID 70614753HCID 70614753, compound

Product 1

HCID 70614840HCID 70614840, compound

Procedure

A further modification of the procedure for preparing 1-(isopropylamino)-3-[4-methylsulfonyl)-m-tolyloxy]-2-propanol employing an epihalohydrin derivative of Formula VII containing a hydrogenolyziable blocking group follows. 1-[(N-Benzyl)isopropylamino]-2,3-epoxypropane is reacted with 4-(methylsulfonyl)-m-cresol sodium salt in ethanol to provide 1-[(N-benzyl)isopropylamino]-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol.

Workup

  1. additioncontaining

Sources & evidence

ORD record
ord-fe5f75a7af1a4b5c89fe44048daf26d3
Source dataset
uspto-grants-1978_10
Patent number
US04119729

Reaction notes

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