Hydrochloric Acid → HCID 15588114, compound

HRID 1112009Notes

Reaction equation

HRID 1112009 reaction equation
C([O:3][C:4]([C:6]1[S:7][C:8]([Cl:18])=[CH:9][C:10]=1[O:11][CH2:12][C:13]([O:15]CC)=[O:14])=[O:5])C.Cl>[OH-].[Na+]>[C:4]([C:6]1[S:7][C:8]([Cl:18])=[CH:9][C:10]=1[O:11][CH2:12][C:13]([OH:15])=[O:14])([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54409902HCID 54409902, compound

Product 1

HCID 15588114HCID 15588114, compoundYield 90.9%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
20 °C

Procedure

A mixture of 2.26 g of the product of Step B and 40 ml of 2N sodium hydroxide was refluxed under nitrogen for 45 minutes and the mixture was cooled to 20° C. 12 ml of 10N hydrochloric acid were added thereto and the mixture was vacuum filtered. The precipitate was washed twice with iced water to obtain 1.66 g of (2-carboxy-5-chloro-3-thienyl)oxyacetic acid melting at 214° C.

Workup

  1. temperaturewas refluxed under nitrogen for 45 minutes
  2. filtrationfiltered
  3. washThe precipitate was washed twice with iced water

Sources & evidence

ORD record
ord-e09d5c08d03142a690f5868dae9b2668
Source dataset
uspto-grants-1978_10
Patent number
US04119727

Reaction notes

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