Ethanol → HCID 501147, compound

HRID 1112064Notes

Reaction equation

HRID 1112064 reaction equation
[C:1]1([CH:7](Cl)[CH2:8][CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na].[SH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N+:15]=1[O-:20].C(O)C>O>[C:1]1([CH:7]([S:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N+:15]=2[O-:20])[CH2:8][CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 524322(1-Chlorobutyl)benzeneHCID 5360545SodiumHCID 178526253HCID 178526253, compound

Product 1

HCID 501147HCID 501147, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 16.9 gms (0.1 mol) of 1-phenylbutylchloride, 36 gms of a 40% aqueous solution of the sodium salt of 2-mercaptopyridine N-oxide (0.1 mol) and 50 ml of ethanol was warmed and stirred at 50° to 60° C. for 2.5 hours. The cooled reaction mixture was poured into 500 ml of water with agitation. The precipitated product was filtered, washed with water and dried. After recrystallization from ethanol a yield of 10 gms (45% theory) of white crystals was obtained.

Workup

  1. temperaturewas warmed
  2. customThe cooled reaction mixture
  3. filtrationThe precipitated product was filtered
  4. washwashed with water
  5. customdried
  6. customAfter recrystallization from ethanol a yield of 10 gms (45% theory) of white crystals
  7. customwas obtained

Sources & evidence

ORD record
ord-fd979cfe795948d489f9728ae3346257
Source dataset
uspto-grants-1978_10
Patent number
US04120692

Reaction notes

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