Acetic Acid → HCID 22765342, compound

HRID 1112199Notes

Reaction equation

HRID 1112199 reaction equation
CO.C(O)(=O)C.C(O)(=O)C.[OH:11][CH:12]([CH2:30][NH:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH2:13][O:14][C:15]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:16]=1[C:17]1[CH:18]=[CH:19][N:20]([CH3:29])[C:21](=[O:28])[C:22]=1[NH:23]2>C(OCC)C>[OH:11][CH:12]([CH2:30][NH:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH2:13][O:14][C:15]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:16]=1[C:17]1[CH:18]=[CH:19][N:20]([CH3:29])[C:21](=[O:28])[C:22]=1[NH:23]2

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 887MethanolHCID 86736070HCID 86736070, compound

Product 1

HCID 22765342HCID 22765342, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The above-obtained base is dissolved in about 50 ml. methanol and mixed with 0.8 ml. glacial acetic acid. After the addition of about 50 ml. diethyl ether, a precipitate is slowly formed. This is filtered off with suction and dried to give 2.6 g. 5(2-hydroxy-3-tert.-butylaminopropoxy)-1-oxo-2-methyl-1,2-dihydro-β-carboline acetate; m.p. 221°-223° C.

Workup

  1. dissolutionThe above-obtained base is dissolved in about 50 ml
  2. additionAfter the addition of about 50 ml
  3. filtrationThis is filtered off with suction
  4. customdried
  5. customto give 2.6 g

Sources & evidence

ORD record
ord-239b179aad824d488afcc0d1383013bd
Source dataset
uspto-grants-1978_10
Patent number
US04120963

Reaction notes

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