Maleimide → 8-(Benzyloxy)-4-(2-chlorophenyl)-9-methoxy-4,5,6,10c-tetrahydropyrrolo[3,4-c]carbazole-1,3(2H,3aH)-dione

HRID 11122Notes

Reaction equation

HRID 11122 reaction equation
[CH2:1]([O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[C:14]([CH:18]=[CH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[NH:15]2)=[CH:11][C:10]=1[O:27][CH3:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:29]1(=[O:35])[NH:33][C:32](=[O:34])[CH:31]=[CH:30]1>>[CH2:1]([O:8][C:9]1[C:10]([O:27][CH3:28])=[CH:11][C:12]2[C:13]3[CH:30]4[C:29](=[O:35])[NH:33][C:32](=[O:34])[CH:31]4[CH:19]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[Cl:26])[CH2:18][C:14]=3[NH:15][C:16]=2[CH:17]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10935MaleimideHCID 86760214HCID 86760214, compound

Product 1

HCID 867602138-(Benzyloxy)-4-(2-chlorophenyl)-9-methoxy-4,5,6,10c-tetrahydropyrrolo[3,4-c]carbazole-1,3(2H,3aH)-dioneYield 87%

Procedure

Reaction of the diene (155) prepared as described in example 255 with maleimide using the procedure described in example 69 gave the adduct (161) as a tan powder (87%), which was used without further purification.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-c4c6b20ef05246859197c01fa797a32d
Source dataset
uspto-grants-2006_08
Patent number
US07094798B1

Reaction notes

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