HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (+)-4-Hydroxy-1,2,9,10-tetramethoxyaporphine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Laudanosine | HCID 73397 | — |
| Catalyst | Sodium orthovanadate | HCID 61671 | — |
| Product | (+)-4-Hydroxy-1,2,9,10-tetramethoxyaporphine | HCID 5259813 | — |
Reaction Steps
2 g. (+)-laudanosine (Eur. J. Med. Chem., 9, 237/1974) is reacted, in the manner described in Example 1, with 1.73 g. vanadyl (V) fluoride in trifluoroacetic acid. After analogous working up and crystallisation from diethyl ether, there is obtained (+)-4-hydroxy-1,2,9,10-tetramethoxyaporphine (cataline) in the form of colourless crystals; m.p. 180° - 182° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04120964 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-d402ab1c972f4bb7a9e22d81e2742579 |
| Source note | uspto-grants-1978_10 |