Hydrochloric Acid → S-[2-(5-methyl-4-imidazolylmethylthio)ethyl]-N-cyano-N'-methylisothiourea hydrochloride

HRID 1112213Notes

Reaction equation

HRID 1112213 reaction equation
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][S:8][CH2:9][CH2:10][SH:11].[ClH:12].[C:13]([NH:15][C:16](=[N:19][CH3:20])SC)#[N:14]>N1C=CC=CC=1.O>[ClH:12].[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][S:8][CH2:9][CH2:10][S:11][C:16](=[N:19][CH3:20])[NH:15][C:13]#[N:14]

Participants

6

Reactant 3

HCID 313Hydrochloric Acid2×HCID 1111031-Cyano-2,3-dimethylisothioureaHCID 203874282-(5-Methyl-4-imidazolylmethylthio)ethanethiol

Product 1

HCID 20387431S-[2-(5-methyl-4-imidazolylmethylthio)ethyl]-N-cyano-N'-methylisothiourea hydrochloride

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1049PyridineSolvent

Procedure

2-(5-Methyl-4-imidazolylmethylthio)ethanethiol (4.0 g) (prepared from the hydrochloride as in Example 1(b) and N-cyano-N', S-dimethylisothiourea (4.0 g) were heated together under nitrogen in pyridine (100 ml) at 100° for 20 hours. After this time the mixture was evaporated to dryness to give the crude title product. This residue taken up in water acidified to pH2 with concentrated hydrochloric acid. After extracting with ethyl acetate the volume of the aqueous fraction was reduced and on cooling gave S-[2-(5-methyl-4-imidazolylmethylthio)ethyl]-N-cyano-N'-methylisothiourea hydrochloride, m.p. 225°.

Workup

  1. customAfter this time the mixture was evaporated to dryness
  2. customto give the crude title product
  3. extractionAfter extracting with ethyl acetate the volume of the aqueous fraction
  4. temperatureon cooling

Sources & evidence

ORD record
ord-4502fce072894240973d9dbc7c8b0ef5
Source dataset
uspto-grants-1978_10
Patent number
US04120966

Reaction notes

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