反应详情

To sodium methoxide (1.90 g., 0.03 mole) in methanol (50 ml.) is added 4,5-methylenedioxy-2-aminobenzaldehyde (5.0 g., 0.03 mole) and 2-cyanoacetamide (2.50 g., 0.03 mole). The mixture is heated to reflux for 15 minutes and then cooled in an ice bath. The bright yellow solid is filtered off and recrystallized from acetic acid to give 6.18 g. (89.3%) of the desired product. M.P. 308° C. (dec.). (m/e) = 231).

1. temperatureThe mixture is heated
2. temperatureto reflux for 15 minutes
3. temperaturecooled in an ice bath
4. filtrationThe bright yellow solid is filtered off
5. customrecrystallized from acetic acid
6. customto give 6.18 g