反应详情

温度

150 °C

A mixture of 6,7-methylenedioxy-2-aminoquinoline-3-carboxamide (1.50 g., 6.5 millimoles), sodium methoxide (0.05 g., 1.25 millimoles) and diethyl oxalate (150 ml.) is heated to 150° C. for 3.5 hours. The mixture is then cooled to room temperature to precipitate the product which is recovered by filtration (1.0 g.). It is purified by chromatography on silica gel using chloroform:methanol (99:1) as eluant. The product is recovered by evaporation of the eluate and recrystallization of the residue from ethanol. Yield = 0.414 g. (20.4%) of the cyclized product. M.P. 267° C. (dec.).

1. temperatureThe mixture is then cooled to room temperature
2. customto precipitate the product which
3. filtrationis recovered by filtration (1.0 g.)
4. customIt is purified by chromatography on silica gel
5. customThe product is recovered by evaporation of the eluate and
6. customrecrystallization of the residue from ethanol