反应详情

Diethyl oxalate (2.35 g., 16.1 millimoles), sodium methoxide (10 mg. and 2-aminonaphthalene-3-carboxamide (1.50 g., 8.05 millimoles) are mixed together and heated at reflux for 2 days. The mixture is then cooled in an ice bath and the brown precipitate recovered by filtration. It is recrystallized from ethanol to give 1.76 g. (79% yield) of the desired ester. M.P. 240°-242° C.

1. temperatureheated
2. temperatureat reflux for 2 days
3. temperatureThe mixture is then cooled in an ice bath
4. filtrationthe brown precipitate recovered by filtration
5. customIt is recrystallized from ethanol
6. customto give 1.76 g