Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Reactant | HCID 11508813 | HCID 11508813 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131711307 | HCID 131711307 | — |
Reaction Steps
687 mg of triethylamine are added to a mixture of 944 mg of Phe-Phe-OMe.HCl D 10 and 1,293 mg of Boc-Pro≈SO2 in 20 ml of absolute tetrahydrofuran, whereupon the mixture develops a deep red coloration. It is stirred for 1 hour at 20° C. The pale yellow mixture is then worked up as described in Example D 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04122090 |
|---|
| Source dataset | uspto-grants-1978_10 |
|---|
| ORD ID | ord-8657edabcea74c9ca30789e0d31671ac |
|---|
| Source note | uspto-grants-1978_10 |
|---|
