Triethylamine → HCID 131711307, compound

HRID 1112338Notes

Reaction equation

HRID 1112338 reaction equation
C(N(CC)CC)C.N[C@H](C([NH:19][C@H:20]([C:28]([O:30][CH3:31])=[O:29])[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=O)CC1C=CC=CC=1.Cl.[N:33]1([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:40][CH2:39][CH2:38][C@H:34]1[C:35]([OH:37])=[O:36]>O1CCCC1>[C:44]([O:43][C:41]([N:33]1[CH2:40][CH2:39][CH2:38][C@H:34]1[C:35]([OH:37])=[O:36])=[O:42])([CH3:47])([CH3:45])[CH3:46].[NH2:19][C@H:20]([C:28]([OH:30])=[O:29])[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[CH3:31][O:30][C:28](=[O:29])[C@H:20]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH2:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-HCID 11508813HCID 11508813, compound

Product 1

HCID 131711307HCID 131711307, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
20 °C

Procedure

687 mg of triethylamine are added to a mixture of 944 mg of Phe-Phe-OMe.HCl D 10 and 1,293 mg of Boc-Pro≈SO2 in 20 ml of absolute tetrahydrofuran, whereupon the mixture develops a deep red coloration. It is stirred for 1 hour at 20° C. The pale yellow mixture is then worked up as described in Example D 1.

Sources & evidence

ORD record
ord-8657edabcea74c9ca30789e0d31671ac
Source dataset
uspto-grants-1978_10
Patent number
US04122090

Reaction notes

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