HRID1112361

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2797

Clofibric acid

C10H11ClO3

结构：CC[C@@]12C=C(C(=O)OC)n3c4c(c5ccccc53)CCN(CCC1)[C@H]42

HCID71204

Methyl (3alpha,16alpha)-eburnamenine-14-carboxylate

C21H24N2O2

PRODUCTS

生成物

结构：CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1.CC[C@@]12C=C(C(=O)OC)n3c4c(c5ccccc53)CCN(CCC1)[C@H]42

HCID70622092

未命名化合物

收率 121%

PROCEDURE

实验过程

The preceding example is repeated starting from 3.36 g of apovincamine and 2.14 g of clofibric acid. The final product (3.5 g) is a low melting solid, m.p. 65° C., which is insoluble in water and soluble in alcohol, with an apovincamine content of 61%.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ef774ae28b334877bd8c60360e247aac
来源数据集: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04122179
来源说明: uspto-grants-1978_10

反应 SMILES

[CH3:1][CH2:2][C@:3]12[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:24][CH2:25][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[CH3:26][C:27]([O:32][C:33]1[CH:34]=[CH:35][C:36]([Cl:39])=[CH:37][CH:38]=1)([C:29]([OH:31])=[O:30])[CH3:28]>>[CH3:1][CH2:2][C@:3]12[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:24][CH2:25][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[CH3:1][CH2:2][O:30][C:29]([C:27]([O:32][C:33]1[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=1)([CH3:26])[CH3:28])=[O:31]