反应详情

Anhydrous acetone (100 ml), potassium carbonate (21 g), p-chlorobenzylmercaptan (19.5 ml), methyl chloroacetate (13.2 ml) and potassium iodide (0.1 g) are mixed in the cold. The mixture thus obtained is stirred and heated under reflux for 7 hours. It is cooled, the precipitate (K2CO3) is filtered off, the acetone is evaporated from the filtrate and the residue is taken up with ether. The ether solution is washed with 4 N NaOH and then with water until the wash waters have a neutral pH. The ether solution is then dried over MgSO4, the ether is evaporated and 34.5 g (100% yield) of methyl p-chlorobenzylmercapto-acetate are collected in the form of a chromatographically pure oil.

1. customThe mixture thus obtained
2. temperatureheated
3. temperatureunder reflux for 7 hours
4. temperatureIt is cooled
5. filtrationthe precipitate (K2CO3) is filtered off
6. customthe acetone is evaporated from the filtrate
7. washThe ether solution is washed with 4 N NaOH
8. dry with materialThe ether solution is then dried over MgSO4
9. customthe ether is evaporated