Sodium borohydride → N-[[2-[3-(4-Morpholinyl)propoxy]phenyl]methyl]benzeneethanamine

HRID 1112442Notes

Reaction equation

HRID 1112442 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH:17]=[N:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[BH4-].[Na+]>CO>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:17][NH:18][CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 20394050N-[[2-[3-(4-Morpholinyl)propoxy]phenyl]methylene]benzeneethanamine

Product 1

HCID 21322756N-[[2-[3-(4-Morpholinyl)propoxy]phenyl]methyl]benzeneethanamine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-[[2-[3-(4-Morpholinyl)propoxy]phenyl]methylene]-benzeneethanamine (17g) is reduced with 5.4g of sodium borohydride in 85 ml of methanol following the procedure described in Example 1B to yield 12.8g of product as an oil, boiling point 219°-223° C at 0.1-0.2 mm of Hg.

Sources & evidence

ORD record
ord-5339cb7e8d0e41b4b42a02452c167729
Source dataset
uspto-grants-1978_10
Patent number
US04122255

Reaction notes

Loading…