Phenethylamine → N-[[2-[3-(1-Piperidinyl)propoxy]phenyl]methylene]benzeneethanamine

HRID 1112449Notes

Reaction equation

HRID 1112449 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=2[CH:13]=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:19]([NH2:27])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C1(C)C=CC=CC=1>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=2[CH:13]=[N:27][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 137952592-[3-(1-Piperidinyl)propoxy]benzaldehyde

Product 1

HCID 21322776N-[[2-[3-(1-Piperidinyl)propoxy]phenyl]methylene]benzeneethanamine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-[3-(1-Piperidinyl)propoxy]benzaldehyde (47.6g) is reacted with 24g of phenethylamine in 190ml of toluene following the procedure described in Example 1A to yield 61.9g of product as an oil, boiling point 214°-218° C. at 0.2-0.3mm of Hg.

Sources & evidence

ORD record
ord-452c04df2d4844e7a3911922bb9fc5f5
Source dataset
uspto-grants-1978_10
Patent number
US04122255

Reaction notes

Loading…