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HRID1112472

反应详情

EQUATION

反应方程式

HRID 1112472 的结构方程式

REACTANTS

反应物

2
结构：O=S(Cl)Cl
HCID24386

Thionyl chloride

Cl2OS

结构：O=C(O)Cn1c(-c2ccccc2)c(-c2ccccc2)oc1=O
HCID10447200

3(2H)-Oxazoleacetic acid, 2-oxo-4,5-diphenyl-

C17H13NO4

PRODUCTS

生成物

1
结构：O=C(Cl)Cn1c(-c2ccccc2)c(-c2ccccc2)oc1=O
HCID10638955

3(2H)-Oxazoleacetyl chloride, 2-oxo-4,5-diphenyl-

C17H12ClNO3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A mixture of 4,5-diphenyl-2-oxo-4-oxazolin-3-ylacetic acid (2.1 g, 7.1 mmol) [J. Org. Chem., 38, 3034 (1973)], thionyl chloride (5 ml) and methylene chloride (20 ml) is refluxed for 2.5 hours. After cooling to room temperature the solvent is removed in vacuo and resulting oil crystallizes on standing. The product is triturated with etherhexane to give 4,5-diphenyl-2-oxo-4-oxazolin-3-ylacetic acid chloride; 2.0 g mp 104°-112°.

WORKUP

后处理

  1. temperatureis refluxed for 2.5 hours
  2. customis removed in vacuo
  3. customresulting oil
  4. customcrystallizes on standing
  5. customThe product is triturated with etherhexane