HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3(2H)-Oxazoleacetyl chloride, 2-oxo-4,5-diphenyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3(2H)-Oxazoleacetic acid, 2-oxo-4,5-diphenyl- | HCID 10447200 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3(2H)-Oxazoleacetyl chloride, 2-oxo-4,5-diphenyl- | HCID 10638955 | — |
Reaction Steps
A mixture of 4,5-diphenyl-2-oxo-4-oxazolin-3-ylacetic acid (2.1 g, 7.1 mmol) [J. Org. Chem., 38, 3034 (1973)], thionyl chloride (5 ml) and methylene chloride (20 ml) is refluxed for 2.5 hours. After cooling to room temperature the solvent is removed in vacuo and resulting oil crystallizes on standing. The product is triturated with etherhexane to give 4,5-diphenyl-2-oxo-4-oxazolin-3-ylacetic acid chloride; 2.0 g mp 104°-112°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04122262 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-bce8a6f76ffb405db7d42db0c3ef4f49 |
| Source note | uspto-grants-1978_10 |