HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethanol → 5-Fluorouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Fluorine | HCID 24524 | — |
| Reactant | Cytosine | HCID 178418229 | — |
| Product | 5-Fluorouracil | HCID 3385 | — |
Reaction Steps
The reaction and the treatment were carried out in the same manner as in Example 1 but using a solution of cytosine (1.11 g) in 2,2,2-trifluoroetanol (100 ml) and blowing the fluorine gas therein at 20° C. to give 5-fluorouracil (0.72 g). Yield, 55%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04122251 |
| Source dataset | uspto-grants-1978_10 |
| ORD ID | ord-a016ecf7848c4cd583de3bed44b49fe8 |
| Source note | uspto-grants-1978_10 |