2,2,2-Trifluoroethanol → 5-Fluorouracil

HRID 1112488Notes

Reaction equation

HRID 1112488 reaction equation
[NH:1]1[CH:8]=CC(N)=[N:4][C:2]1=[O:3].FF.[F:11][C:12](F)(F)[CH2:13][OH:14]>>[F:11][C:12]1[C:13](=[O:14])[NH:4][C:2](=[O:3])[NH:1][CH:8]=1

Participants

4

Reactant 3

HCID 64092,2,2-TrifluoroethanolHCID 24524FluorineHCID 178418229Cytosine

Product 1

HCID 33855-Fluorouracil

Procedure

The reaction and the treatment were carried out in the same manner as in Example 1 but using a solution of cytosine (1.11 g) in 2,2,2-trifluoroetanol (100 ml) and blowing the fluorine gas therein at 20° C. to give 5-fluorouracil (0.72 g). Yield, 55%.

Workup

  1. customThe reaction

Sources & evidence

ORD record
ord-a016ecf7848c4cd583de3bed44b49fe8
Source dataset
uspto-grants-1978_10
Patent number
US04122251

Reaction notes

Loading…