反应详情

A stirred mixture of 4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carbonitrile (2.17 g., 0.0127 mole), sodium azide (0.911 g., 0.014 mole), and ammonium chloride (0.75 g., 0.014 mole) in N,N-dimethylformamide (20 ml.) was heated by means of an oil bath maintained at 120° for 19 hours. The solvent was removed and the residue treated with hot aqueous sodium bicarbonate. The mixture was filtered. The filtrate was acidified with acetic acid. The precipitate was collected and recrystallized from acetic acid to give the title compound (0.52 g., 19%) m.p. 308°-309° (decomp). Recrystallization from acetic acid with charcoal treatment gave analytical material, m.p. 311°-312° (decomp).

1. temperaturewas heated by means of an oil bath
2. temperaturemaintained at 120° for 19 hours
3. customThe solvent was removed
4. additionthe residue treated with hot aqueous sodium bicarbonate
5. filtrationThe mixture was filtered
6. customThe precipitate was collected
7. customrecrystallized from acetic acid