2-Amino-6-(1-piperidinyl)benzonitrile → N-[2-cyano-3-(1-piperidinyl)phenyl]-1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide

HRID 1112589Notes

Reaction equation

HRID 1112589 reaction equation
[N:1]1([C:7]2[CH:14]=[CH:13][CH:12]=[C:11]([NH2:15])[C:8]=2[C:9]#[N:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:16][O:17][C:18]1[CH:32]=[CH:31][C:21]([CH2:22][N:23]2[C:27]([C:28](Cl)=[O:29])=[N:26][N:25]=[N:24]2)=[CH:20][CH:19]=1>N1C=CC=CC=1>[C:9]([C:8]1[C:7]([N:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)=[CH:14][CH:13]=[CH:12][C:11]=1[NH:15][C:28]([C:27]1[N:23]([CH2:22][C:21]2[CH:31]=[CH:32][C:18]([O:17][CH3:16])=[CH:19][CH:20]=2)[N:24]=[N:25][N:26]=1)=[O:29])#[N:10]

Participants

4

Reactant 2

HCID 127157252-Amino-6-(1-piperidinyl)benzonitrileHCID 204638701-(4-methoxybenzyl)-1H-tetrazole-5-carbonyl chloride

Product 1

HCID 12752385N-[2-cyano-3-(1-piperidinyl)phenyl]-1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The N-[2-cyano-3-(1-piperidinyl)phenyl]-1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide was prepared in the usual manner as illustrated in Example I from 2-(1-piperidinyl)-6-aminobenzonitrile and 1-p-methoxybenzyl-5-tetrazolecarbonylchloride in the presence of pyridine. The product was recrystallized from acetonitrile, m.p. 166°-168° C.

Workup

  1. customThe product was recrystallized from acetonitrile, m.p. 166°-168° C.

Sources & evidence

ORD record
ord-444fc59c7d004ac4a5b867087ce036f7
Source dataset
uspto-grants-1978_10
Patent number
US04123432

Reaction notes

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