HCID 8590733, compound → HCID 22762560, compound

HRID 1112735Notes

Reaction equation

HRID 1112735 reaction equation
[C:1]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19]4[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=4)[CH2:15][CH2:14]3)=[N:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>C(O)(=O)C.[Pd]>[C:1]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH2:14][CH2:15][N:16]([C:19]4[CH:20]=[CH:21][C:22]([NH2:25])=[CH:23][CH:24]=4)[CH2:17][CH2:18]3)=[N:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 8590733HCID 8590733, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22762560HCID 22762560, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A solution of 1-(5-phenyloxazol-2-ylmethyl)-4-(4-nitrophenyl)-piperazine (7.28 g; 0.02 mole) in glacial acetic acid (50 ml) was hydrogenated over 5% Palladium-on-charcoal catalyst (100 mg) at atmospheric pressure and room temperature, until the uptake of hydrogen was complete. The solvent was evaporated off under vacuum and the residue treated with aqueous sodium bicarbonate solution, yielding a white crystalline solid. Weight after drying = 6.54 g (98%), m.p. 130° C.

Workup

  1. customThe solvent was evaporated off under vacuum
  2. additionthe residue treated with aqueous sodium bicarbonate solution
  3. customyielding a white crystalline solid
  4. customWeight after drying = 6.54 g (98%), m.p. 130° C.

Sources & evidence

ORD record
ord-9a551db3f2e3431a918c6f86910ea82c
Source dataset
uspto-grants-1978_10
Patent number
US04123529

Reaction notes

Loading…