HCID 8590733, compound → HCID 22762560, compound

Participants

Reaction Steps

A solution of 1-(5-phenyloxazol-2-ylmethyl)-4-(4-nitrophenyl)-piperazine (7.28 g; 0.02 mole) in glacial acetic acid (50 ml) was hydrogenated over 5% Palladium-on-charcoal catalyst (100 mg) at atmospheric pressure and room temperature, until the uptake of hydrogen was complete. The solvent was evaporated off under vacuum and the residue treated with aqueous sodium bicarbonate solution, yielding a white crystalline solid. Weight after drying = 6.54 g (98%), m.p. 130° C.

Provenance & Evidence