Potassium Carbonate → HCID 22763000, compound

HRID 1112773Notes

Reaction equation

HRID 1112773 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2([CH3:13])[CH2:12][O:11]2)=[CH:4][CH:3]=1.[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[SH:21].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([CH3:13])([OH:11])[CH2:12][S:21][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[Cl:14])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 80599o-ChlorothiophenolHCID 22762984HCID 22762984, compound

Product 1

HCID 22763000HCID 22763000, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 4 g. of 2-[2-(4-chlorophenyl)ethyl]-2-methyloxirane, 3.6 g. of 2-chlorothiophenol and 500 mg. of anhydrous potassium carbonate in 50 ml. of acetone is stirred at reflux for approximately 3 hours. The solvent is then evaporated and 200 ml. of ether is added to the residue. The resulting mixture is washed with water (3 × 40 ml.), dried (MgSO4) and evaporated to afford 4-(4-chlorophenyl)-1-(2-chlorophenylthio)-2-methyl-2-butanol which is used directly as described later in the procedure.

Workup

  1. additionA mixture of 4 g
  2. temperatureat reflux for approximately 3 hours
  3. customThe solvent is then evaporated
  4. additionof ether is added to the residue
  5. washThe resulting mixture is washed with water (3 × 40 ml.)
  6. dry with materialdried (MgSO4)
  7. customevaporated

Sources & evidence

ORD record
ord-9a2e21a7642d489c88b2fef01c8fdb00
Source dataset
uspto-grants-1978_10
Patent number
US04123542

Reaction notes

Loading…