Dichloromethane → 4-(4-Chloro-phenyl)-3-methyl-piperidin-4-ol

HRID 1112860Notes

Reaction equation

HRID 1112860 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([CH3:22])[C:11]([OH:14])([c:15]2[cH:16][cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:30][CH2:31][Cl:32].[OH:23][C:24]([C:25]([F:26])([F:27])[F:28])=[O:29]>>[NH:8]1[CH2:9][CH:10]([CH3:22])[C:11]([OH:14])([c:15]2[cH:16][cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59444243Tert-butyl 4-(4-chlorophenyl)-4-hydroxy-3-methylpiperidine-1-carboxylate

Product 1

HCID 231370704-(4-Chloro-phenyl)-3-methyl-piperidin-4-ol

Sources & evidence

ORD record
ord-59b2e92b8e314977b75d9c7eda3ac0c4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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