Ethyl Acetate → 4-Chloro-6-[2,2,2-trifluoro-1-(4-pyridin-4-yl-phenyl)-ethoxy]-pyrimidin-2-ylamine
Reaction equation
[C:28](=[O:29])([O-:30])[O-:31].[CH2:40]1[O:41][CH2:42][CH2:43][O:44][CH2:45]1.[CH3:34][CH2:35][O:36][C:37](=[O:38])[CH3:39].[Cs+:32].[Cs+:33].[F:1][C:2]([CH:3]([OH:4])[c:5]1[cH:6][cH:7][c:8](-[c:11]2[cH:12][cH:13][n:14][cH:15][cH:16]2)[cH:9][cH:10]1)([F:17])[F:18].[NH2:19][c:20]1[n:21][c:22]([Cl:27])[cH:23][c:24]([Cl:26])[n:25]1>>[F:1][C:2]([CH:3]([O:4][c:24]1[cH:23][c:22]([Cl:27])[n:21][c:20]([NH2:19])[n:25]1)[c:5]1[cH:6][cH:7][c:8](-[c:11]2[cH:12][cH:13][n:14][cH:15][cH:16]2)[cH:9][cH:10]1)([F:17])[F:18]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-26550d3ae8e1470d9fac25e60f29c20c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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