Methanol → 3-[5-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-1-ol

HRID 1113275Notes

Reaction equation

HRID 1113275 reaction equation
[Br:30][CH2:31][CH2:32][CH2:33][OH:34].[C:1](=[O:2])([O-:3])[O-:4].[CH3:35][OH:36].[CH3:7][S:8](=[O:9])(=[O:10])[N:11]1[CH2:12][c:13]2[c:14]([nH:17][n:18][c:19]2-[c:20]2[cH:21][cH:22][c:23]([C:26]([F:27])([F:28])[F:29])[cH:24][cH:25]2)[CH2:15][CH2:16]1.[Cs+:5].[Cs+:6].[O:37]=[CH:38][N:39]([CH3:40])[CH3:41].[OH2:42]>>[CH3:7][S:8](=[O:9])(=[O:10])[N:11]1[CH2:12][c:13]2[c:14]([n:17]([CH2:31][CH2:32][CH2:33][OH:34])[n:18][c:19]2-[c:20]2[cH:21][cH:22][c:23]([C:26]([F:27])([F:28])[F:29])[cH:24][cH:25]2)[CH2:15][CH2:16]1

Participants

8

Reactant 7

HCID 887MethanolHCID 962WaterHCID 6228DimethylformamideHCID 123083-Bromo-1-propanolHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 120720305-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Product 1

HCID 222936223-[5-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-1-ol

Sources & evidence

ORD record
ord-fa06a37a2e40414c9ca6e34884db5ccd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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