Dichloromethane → (4-((((1,1-Dimethylethyl)(dimethyl)silyl)oxy)methyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-yl)(1-methylcyclopropyl)methanol

HRID 1113405Notes

Reaction equation

HRID 1113405 reaction equation
[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][c:10]([CH:23]([C:24](=[CH2:25])[CH3:26])[OH:27])[c:11](-[c:14]2[c:15]([F:22])[cH:16][cH:17][c:18]([O:20][CH3:21])[cH:19]2)[cH:12][cH:13]1)([CH3:28])[CH3:29].[CH3:33][CH2:34][Zn:35][CH2:36][CH3:37].[Cl:38][CH2:39][Cl:40].[I:30][CH2:31][I:32]>>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][c:10]([CH:23]([C:24]2([CH3:31])[CH2:25][CH2:26]2)[OH:27])[c:11](-[c:14]2[c:15]([F:22])[cH:16][cH:17][c:18]([O:20][CH3:21])[cH:19]2)[cH:12][cH:13]1)([CH3:28])[CH3:29]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6346DiiodomethaneHCID 577055531-(4-((((1,1-Dimethylethyl)(dimethyl)silyl)oxy)methyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-yl)-2-methyl-2-propen-1-olHCID 178418750HCID 178418750, compound

Product 1

HCID 57706611(4-((((1,1-Dimethylethyl)(dimethyl)silyl)oxy)methyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-yl)(1-methylcyclopropyl)methanol

Sources & evidence

ORD record
ord-daa57baf687a4b79b6cf5b477e7c37e3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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