Dichloromethane → 3-amino-N-[2-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]-2-pyrazinecarboxamide

HRID 1113720Notes

Reaction equation

HRID 1113720 reaction equation
[CH2:11]([N:12]([CH2:13][CH2:14][CH2:15][CH3:16])[CH2:17][CH2:18][CH2:19][CH3:20])[CH2:21][CH2:22][CH3:23].[Cl:51][CH2:52][Cl:53].[NH2:1][c:2]1[c:3]([C:8](=[O:9])[OH:10])[n:4][cH:5][cH:6][n:7]1.[NH2:24][CH2:25][CH2:26][N:27]1[CH2:28][CH2:29][CH:30]([NH:33][c:34]2[n:35][c:36]3[c:37]([n:38]2[CH2:39][c:40]2[cH:41][cH:42][c:43]([F:46])[cH:44][cH:45]2)[cH:47][cH:48][cH:49][cH:50]3)[CH2:31][CH2:32]1>>[NH2:1][c:2]1[c:3]([C:8](=[O:10])[NH:24][CH2:25][CH2:26][N:27]2[CH2:28][CH2:29][CH:30]([NH:33][c:34]3[n:35][c:36]4[c:37]([n:38]3[CH2:39][c:40]3[cH:41][cH:42][c:43]([F:46])[cH:44][cH:45]3)[cH:47][cH:48][cH:49][cH:50]4)[CH2:31][CH2:32]2)[n:4][cH:5][cH:6][n:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 7622TributylamineHCID 726563-Amino-2-pyrazinecarboxylic acidHCID 12891741N-[1-(2-aminoethyl)-4-piperidinyl]-1-(4-fluorophenylmethyl)-1H-benzimidazol-2-amine

Product 1

HCID 135881203-amino-N-[2-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]-2-pyrazinecarboxamide

Sources & evidence

ORD record
ord-15f9623d1f8a42d59a39ae8d0efba1ac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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