Methanol → 2-[3-(2-chlorophenoxy)-5-oxo-2H-pyrrol-1-yl]-N-[1-(2,3-dihydroxypropyl)pyrazol-3-yl]-4,4-difluoropentanamide

HRID 1114180Notes

Reaction equation

HRID 1114180 reaction equation
[CH3:1][C:2]1([CH3:36])[O:3][CH2:4][CH:5]([CH2:7][n:8]2[n:9][c:10]([NH:13][C:14]([CH:15]([CH2:16][C:17]([CH3:18])([F:19])[F:20])[N:21]3[C:22](=[O:34])[CH:23]=[C:24]([O:26][c:27]4[c:28]([Cl:33])[cH:29][cH:30][cH:31][cH:32]4)[CH2:25]3)=[O:35])[cH:11][cH:12]2)[O:6]1.[CH3:48][OH:49].[c:37]1([CH3:38])[cH:39][cH:40][c:41]([S:42]([OH:43])(=[O:44])=[O:45])[cH:46][cH:47]1>>[OH:3][CH2:4][CH:5]([OH:6])[CH2:7][n:8]1[n:9][c:10]([NH:13][C:14]([CH:15]([CH2:16][C:17]([CH3:18])([F:19])[F:20])[N:21]2[C:22](=[O:34])[CH:23]=[C:24]([O:26][c:27]3[c:28]([Cl:33])[cH:29][cH:30][cH:31][cH:32]3)[CH2:25]2)=[O:35])[cH:11][cH:12]1

Participants

4

Reactant 3

HCID 887MethanolHCID 6101p-Toluenesulfonic acidHCID 178461137HCID 178461137, compound

Product 1

HCID 1784611382-[3-(2-chlorophenoxy)-5-oxo-2H-pyrrol-1-yl]-N-[1-(2,3-dihydroxypropyl)pyrazol-3-yl]-4,4-difluoropentanamide

Sources & evidence

ORD record
ord-244be7c082424ec8b648e4b4c38dc0ab
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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