Dichloromethane → 1-Chloro-6-(piperidin-3-yloxy)isoquinoline

HRID 1114200Notes

Reaction equation

HRID 1114200 reaction equation
[C:8]([O:9][C:10](=[O:11])[N:15]1[CH2:16][CH:17]([O:21][c:22]2[cH:23][c:24]3[cH:25][cH:26][n:27][c:28]([Cl:32])[c:29]3[cH:30][cH:31]2)[CH2:18][CH2:19][CH2:20]1)([CH3:12])([CH3:13])[CH3:14].[Cl:33][CH2:34][Cl:35].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[NH:15]1[CH2:16][CH:17]([O:21][c:22]2[cH:23][c:24]3[cH:25][cH:26][n:27][c:28]([Cl:32])[c:29]3[cH:30][cH:31]2)[CH2:18][CH2:19][CH2:20]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 866129773-(1-Chloroisoquinolin-6-yloxy)piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 866129781-Chloro-6-(piperidin-3-yloxy)isoquinoline

Sources & evidence

ORD record
ord-7925d3b8a8134f18a7ad8ae2f4c05c0e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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