Dichloromethane → HCID 11341301, compound

HRID 1114386Notes

Reaction equation

HRID 1114386 reaction equation
[CH:38]([N:39]([CH:40]([CH3:41])[CH3:42])[CH2:43][CH3:44])([CH3:45])[CH3:46].[Cl:10][c:11]1[c:12]([F:37])[c:13]([NH:14][c:15]2[n:16][cH:17][n:18][c:19]3[cH:20][c:21]([O:32][CH3:33])[c:22]([O:25][CH:26]4[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]4)[cH:23][c:24]23)[cH:34][cH:35][cH:36]1.[Cl:47][CH2:48][Cl:49].[O:1]1[CH2:2][CH2:3][N:4]([C:7](=[O:8])[Cl:9])[CH2:5][CH2:6]1>>[O:1]1[CH2:2][CH2:3][N:4]([C:7](=[O:8])[N:29]2[CH2:28][CH2:27][CH:26]([O:25][c:22]3[c:21]([O:32][CH3:33])[cH:20][c:19]4[n:18][cH:17][n:16][c:15]([NH:14][c:13]5[c:12]([F:37])[c:11]([Cl:10])[cH:36][cH:35][cH:34]5)[c:24]4[cH:23]3)[CH2:31][CH2:30]2)[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 848104-Morpholinecarbonyl chlorideHCID 10408840N-(3-chloro-2-fluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine

Product 1

HCID 11341301HCID 11341301, compound

Sources & evidence

ORD record
ord-d30d82bf9a6e40aaa5f49550d3349e35
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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