Trifluoroacetic acid → racemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-1'-ethyl-2'-(2-methylphenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 1114419Notes

Reaction equation

HRID 1114419 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[C:9](=[O:40])[C:10]2([c:11]3[cH:12][cH:13][c:14]([Cl:17])[cH:15][c:16]31)[CH:18]([c:33]1[c:34]([CH3:39])[cH:35][cH:36][cH:37][cH:38]1)[N:19]([CH2:31][CH3:32])[C:20](=[O:30])[CH2:21][CH:22]2[c:23]1[cH:24][c:25]([Cl:29])[cH:26][cH:27][cH:28]1)([CH3:5])([CH3:6])[CH3:7].[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47]>>[NH:8]1[C:9](=[O:40])[C:10]2([c:11]3[cH:12][cH:13][c:14]([Cl:17])[cH:15][c:16]31)[CH:18]([c:33]1[c:34]([CH3:39])[cH:35][cH:36][cH:37][cH:38]1)[N:19]([CH2:31][CH3:32])[C:20](=[O:30])[CH2:21][CH:22]2[c:23]1[cH:24][c:25]([Cl:29])[cH:26][cH:27][cH:28]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 90883474racemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-1'-ethyl-2,3-dihydro-2'-(2-methylphenyl)-2,6'-dioxo spiro[indole-3,3'-piperidine]-1-carboxylic acid tert-butyl ester

Product 1

HCID 131727319racemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-1'-ethyl-2'-(2-methylphenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Sources & evidence

ORD record
ord-a59850b5cda946f5bfc84465267b4198
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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