Hydrochloric Acid → 2-[2-Chloro-5-(trifluoromethyl)phenyl]-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

HRID 1114526Notes

Reaction equation

HRID 1114526 reaction equation
[Cl:48][c:49]1[c:50]([CH2:59][C:60](=[O:61])[OH:62])[cH:51][c:52]([C:55]([F:56])([F:57])[F:58])[cH:53][cH:54]1.[ClH:1].[c:21]1([CH2:22][CH2:23][c:24]2[n:25][c:26]([CH:27]3[CH2:28][CH2:29][N:30]([C:31](=[O:32])[CH2:33][c:34]4[cH:35][cH:36][s:37][cH:38]4)[CH2:39][CH2:40]3)[s:41][cH:42]2)[cH:43][cH:44][cH:45][cH:46][cH:47]1.[c:2]1([CH2:8][CH2:9][c:10]2[n:11][c:12]([CH:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[s:13][cH:14]2)[cH:3][cH:4][cH:5][cH:6][cH:7]1>>[c:2]1([CH2:8][CH2:9][c:10]2[n:11][c:12]([CH:15]3[CH2:16][CH2:17][N:18]([C:60]([CH2:59][c:50]4[c:49]([Cl:48])[cH:54][cH:53][c:52]([C:55]([F:56])([F:57])[F:58])[cH:51]4)=[O:61])[CH2:19][CH2:20]3)[s:13][cH:14]2)[cH:3][cH:4][cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 27781192-(2-Chloro-5-(trifluoromethyl)phenyl)acetic acidHCID 671566001-{4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-(thiophen-3-yl)ethanoneHCID 671568844-(2-Phenylethyl)-2-piperidin-4-yl-1,3-thiazole

Product 1

HCID 671564182-[2-Chloro-5-(trifluoromethyl)phenyl]-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

Sources & evidence

ORD record
ord-47daf29bb89041549718105fba6e0de3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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