Potassium Cation → 2-Chloro-6-[3-(4-methyl-piperazin-1-yl)-prop-1-ynyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

HRID 1115279Notes

Reaction equation

HRID 1115279 reaction equation
[C:25](=[O:26])([O-:27])[O-:28].[CH3:31][N:32]1[CH2:33][CH2:34][NH:35][CH2:36][CH2:37]1.[CH3:38][C:39]#[N:40].[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([C:11]#[C:12][CH2:13][O:14][S:15]([CH3:16])(=[O:17])=[O:18])[s:10]2.[Cl:41][CH2:42][Cl:43].[K+:29].[K+:30]>>[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([C:11]#[C:12][CH2:13][N:35]1[CH2:34][CH2:33][N:32]([CH3:31])[CH2:37][CH2:36]1)[s:10]2

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 6342AcetonitrileHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 531671-MethylpiperazineHCID 86618394Methanesulfonic acid 3-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl)-prop-2-ynyl ester

Product 1

HCID 866183952-Chloro-6-[3-(4-methyl-piperazin-1-yl)-prop-1-ynyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-8fb6998d624643068e4a0475931666ed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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