Water → N-[4-chloro-2-hydroxy-5-trifluoromethylphenyl]isonicotinamide

HRID 1115926Notes

Reaction equation

HRID 1115926 reaction equation
[NH2:1][c:2]1[c:3]([OH:13])[cH:4][c:5]([Cl:12])[c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1.[OH2:29].[OH:14][C:15](=[O:16])[c:17]1[cH:18][cH:19][n:20][cH:21][cH:22]1.[cH:23]1[cH:24][cH:25][n:26][cH:27][cH:28]1>>[NH:1]([c:2]1[c:3]([OH:13])[cH:4][c:5]([Cl:12])[c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1)[C:15](=[O:14])[c:17]1[cH:18][cH:19][n:20][cH:21][cH:22]1

Participants

5

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 5922Isonicotinic AcidHCID 140117362-Amino-5-chloro-4-(trifluoromethyl)phenol

Product 1

HCID 66880038N-[4-chloro-2-hydroxy-5-trifluoromethylphenyl]isonicotinamide

Sources & evidence

ORD record
ord-26905877b24741748638093fba0ef40b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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