Dichloromethane → N-[3-[5-amino-3-(difluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide

HRID 1116794Notes

Reaction equation

HRID 1116794 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][C:8]1=[N:13][C:12]([CH:14]([F:15])[F:16])([c:17]2[c:18]([F:35])[cH:19][cH:20][c:21]([NH:23][C:24](=[O:25])[c:26]3[n:27][cH:28][c:29]([C:33]#[N:34])[cH:30][c:31]3[CH3:32])[cH:22]2)[CH2:11][O:10][CH2:9]1)([CH3:5])([CH3:6])[CH3:36].[Cl:44][CH2:45][Cl:46].[F:37][C:38]([F:39])([F:40])[C:41]([OH:42])=[O:43]>>[NH2:7][C:8]1=[N:13][C:12]([CH:14]([F:15])[F:16])([c:17]2[c:18]([F:35])[cH:19][cH:20][c:21]([NH:23][C:24](=[O:25])[c:26]3[n:27][cH:28][c:29]([C:33]#[N:34])[cH:30][c:31]3[CH3:32])[cH:22]2)[CH2:11][O:10][CH2:9]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66665272tert-butyl N-[5-[5-[(5-cyano-3-methylpyridine-2-carbonyl)amino]-2-fluorophenyl]-5-(difluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]carbamate

Product 1

HCID 66666028N-[3-[5-amino-3-(difluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide

Sources & evidence

ORD record
ord-0a9019009c0a49879376ee1997823ad6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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