Bromobenzene → 2-(3-Bromo-phenyl)-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine

HRID 1116803Notes

Reaction equation

HRID 1116803 reaction equation
[BH:18]([OH:19])[OH:20].[Br:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[Cl:1][c:2]1[n:3][c:4]([C:14]([F:15])([F:16])[F:17])[cH:5][c:6](-[c:8]2[s:9][c:10]([Cl:13])[cH:11][cH:12]2)[n:7]1>>[c:2]1(-[c:26]2[cH:25][cH:24][cH:23][c:22]([Br:21])[cH:27]2)[n:3][c:4]([C:14]([F:15])([F:16])[F:17])[cH:5][c:6](-[c:8]2[s:9][c:10]([Cl:13])[cH:11][cH:12]2)[n:7]1

Participants

4

Reactant 3

HCID 7961BromobenzeneHCID 61668Boronic AcidHCID 866246272-Chloro-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine

Product 1

HCID 673946642-(3-Bromo-phenyl)-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine

Sources & evidence

ORD record
ord-9c480f848a14485fb976a434e72b5b39
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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