Dichloromethane → N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

HRID 1117776Notes

Reaction equation

HRID 1117776 reaction equation
[CH3:1][c:2]1[c:3]([CH2:10][NH:11][C:12](=[O:13])[c:14]2[c:15]3[c:16]([n:17][c:18]([C:20]4=[CH:21][CH2:22][N:23]([C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:24][CH2:25]4)[cH:19]2)[n:33]([CH:36]([CH3:37])[CH3:38])[n:34][cH:35]3)[c:4](=[O:9])[nH:5][c:6]([CH3:8])[cH:7]1.[Cl:39][CH2:40][Cl:41].[F:42][C:43]([F:44])([F:45])[C:46]([OH:47])=[O:48]>>[CH3:1][c:2]1[c:3]([CH2:10][NH:11][C:12](=[O:13])[c:14]2[c:15]3[c:16]([n:17][c:18]([C:20]4=[CH:21][CH2:22][NH:23][CH2:24][CH2:25]4)[cH:19]2)[n:33]([CH:36]([CH3:37])[CH3:38])[n:34][cH:35]3)[c:4](=[O:9])[nH:5][c:6]([CH3:8])[cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68295103tert-butyl 4-(4-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 68294868N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Sources & evidence

ORD record
ord-0d192e22d9cd42e4a78454e7280600ef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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