Chloroform → Methyl 2-[[1-[4-[[[(4-fluorophenyl)methyl]amino]carbonyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]amino]-2-oxoacetate

HRID 1118055Notes

Reaction equation

HRID 1118055 reaction equation
[CH2:25]([N:26]([CH2:27][CH3:28])[CH2:29][CH3:30])[CH3:31].[CH:39]([Cl:40])([Cl:41])[Cl:42].[Cl:32][C:33]([C:34](=[O:35])[O:36][CH3:37])=[O:38].[NH2:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6]([CH3:24])[c:7](=[O:23])[c:8]([OH:22])[c:9]([C:11](=[O:12])[NH:13][CH2:14][c:15]2[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]2)[n:10]1>>[NH:1]([C:2]([CH3:3])([CH3:4])[c:5]1[n:6]([CH3:24])[c:7](=[O:23])[c:8]([OH:22])[c:9]([C:11](=[O:12])[NH:13][CH2:14][c:15]2[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]2)[n:10]1)[C:33]([C:34](=[O:35])[O:36][CH3:37])=[O:38]

Participants

5

Reactant 4

HCID 6212ChloroformHCID 8471TriethylamineHCID 79846Methyl chloroglyoxylateHCID 547218802-(2-Aminopropan-2-yl)-N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

Product 1

HCID 54737243Methyl 2-[[1-[4-[[[(4-fluorophenyl)methyl]amino]carbonyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]amino]-2-oxoacetate

Sources & evidence

ORD record
ord-d1347274083f4cb0b86b94de6e9b1769
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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