Acetone → N-{2-tert-Butyl-5-[3-(3-cyano-phenyl)-3-hydroxy-cyclobutyl]-2H-pyrazol-3-yl}-2,2,2-trifluoro-acetamide
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:5]#[N:6])[cH:7][cH:8][cH:9]1.[C:14](=[O:15])=[O:16].[C:22]([CH3:23])([CH3:24])([CH3:25])[n:26]1[n:27][c:28]([CH:38]2[CH2:39][C:40](=[O:42])[CH2:41]2)[cH:29][c:30]1[NH:31][C:32]([C:33]([F:34])([F:35])[F:36])=[O:37].[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:10][C:11](=[O:12])[CH3:13].[CH3:17][CH2:18][CH2:19][CH2:20][Li:21]>>[c:2]1([C:40]2([OH:42])[CH2:39][CH:38]([c:28]3[n:27][n:26]([C:22]([CH3:23])([CH3:24])[CH3:25])[c:30]([NH:31][C:32]([C:33]([F:34])([F:35])[F:36])=[O:37])[cH:29]3)[CH2:41]2)[cH:3][c:4]([C:5]#[N:6])[cH:7][cH:8][cH:9]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-cf3ea06f0da54569ba3d217ec585232c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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