Water → 3-[3,5-difluoro-4-[1-(3-hydroxypropanoyl)-3,6-dihydro-2H-pyridin-4-yl]phenyl]-5-[(1,2-oxazol-3-ylamino)methyl]-1,3-oxazolidin-2-one

HRID 1118455Notes

Reaction equation

HRID 1118455 reaction equation
[Cl:47][CH2:48][Cl:49].[OH2:50].[OH:1][CH2:2][CH2:3][C:4](=[O:5])[N:6]1[CH2:7][CH:8]=[C:9]([c:12]2[c:13]([F:39])[cH:14][c:15]([N:19]3[C:20](=[O:38])[O:21][CH:22]([CH2:24][N:25]([C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[c:33]4[n:34][o:35][cH:36][cH:37]4)[CH2:23]3)[cH:16][c:17]2[F:18])[CH2:10][CH2:11]1.[OH:40][C:41]([C:42]([F:43])([F:44])[F:45])=[O:46]>>[OH:1][CH2:2][CH2:3][C:4](=[O:5])[N:6]1[CH2:7][CH:8]=[C:9]([c:12]2[c:13]([F:39])[cH:14][c:15]([N:19]3[C:20](=[O:38])[O:21][CH:22]([CH2:24][NH:25][c:33]4[n:34][o:35][cH:36][cH:37]4)[CH2:23]3)[cH:16][c:17]2[F:18])[CH2:10][CH2:11]1

Participants

5

Reactant 4

HCID 962WaterHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 178453105HCID 178453105, compound

Product 1

HCID 777379803-[3,5-difluoro-4-[1-(3-hydroxypropanoyl)-3,6-dihydro-2H-pyridin-4-yl]phenyl]-5-[(1,2-oxazol-3-ylamino)methyl]-1,3-oxazolidin-2-one

Sources & evidence

ORD record
ord-7d836d0f639a4682a3a17a96b606a572
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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