Trifluoroacetic acid → 4-((azetidin-3-yl)methoxy)-N-(cis-4-methylcyclohexyl)-5-(4-morpholinophenyl)pyrimidin-2-amine

HRID 1118707Notes

Reaction equation

HRID 1118707 reaction equation
[CH3:1][CH:2]1[CH2:3][CH2:4][CH:5]([NH:8][c:9]2[n:10][cH:11][c:12](-[c:28]3[cH:29][cH:30][c:31]([N:34]4[CH2:35][CH2:36][O:37][CH2:38][CH2:39]4)[cH:32][cH:33]3)[c:13]([O:15][CH2:16][CH:17]3[CH2:18][N:19]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:20]3)[n:14]2)[CH2:6][CH2:7]1.[F:40][C:41]([F:42])([F:43])[C:44]([OH:45])=[O:46]>>[CH3:1][CH:2]1[CH2:3][CH2:4][CH:5]([NH:8][c:9]2[n:10][cH:11][c:12](-[c:28]3[cH:29][cH:30][c:31]([N:34]4[CH2:35][CH2:36][O:37][CH2:38][CH2:39]4)[cH:32][cH:33]3)[c:13]([O:15][CH2:16][CH:17]3[CH2:18][NH:19][CH2:20]3)[n:14]2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71108027Tert-butyl 3-((2-(cis-4-methylcyclohexylamino)-5-(4-morpholinophenyl)pyrimidin-4-yloxy)methyl)azetidine-1-carboxylate

Product 1

HCID 711080444-((azetidin-3-yl)methoxy)-N-(cis-4-methylcyclohexyl)-5-(4-morpholinophenyl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-7722684abeb34530925e58edabf12f0c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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