Methanol → N-(3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)-2-hydroxyacetamide

HRID 1118778Notes

Reaction equation

HRID 1118778 reaction equation
[C:1](=[O:2])([CH3:3])[O:4][CH2:5][C:6](=[O:7])[NH:8][c:9]1[c:10]([C:36]([CH3:37])=[O:38])[c:11](=[O:35])[n:12]([CH3:34])[c:13]2[n:14][c:15](-[c:26]3[c:27]([Cl:33])[cH:28][c:29]([Cl:32])[cH:30][cH:31]3)[c:16](-[c:19]3[cH:20][cH:21][c:22]([Cl:25])[cH:23][cH:24]3)[cH:17][c:18]12.[C:39](=[O:40])([O-:41])[O-:42].[CH3:48][OH:49].[CH3:50][CH2:51][O:52][C:53]([CH3:54])=[O:55].[Cl:45][CH2:46][Cl:47].[Cs+:43].[Cs+:44]>>[OH:4][CH2:5][C:6](=[O:7])[NH:8][c:9]1[c:10]([C:36]([CH3:37])=[O:38])[c:11](=[O:35])[n:12]([CH3:34])[c:13]2[n:14][c:15](-[c:26]3[c:27]([Cl:33])[cH:28][c:29]([Cl:32])[cH:30][cH:31]3)[c:16](-[c:19]3[cH:20][cH:21][c:22]([Cl:25])[cH:23][cH:24]3)[cH:17][c:18]12

Participants

7

Reactant 6

HCID 887MethanolHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 113651622-{[3-Acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]amino}-2-oxoethyl acetate

Product 1

HCID 11341568N-(3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)-2-hydroxyacetamide

Sources & evidence

ORD record
ord-8caaf8dda10e4278b9026ecd5ee431b9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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