Potassium Cation → 4-Fluoro-N-[5-(5-methoxy-2-trifluoromethyl-benzoimidazol-1-yl)-pyrazin-2-yl]-benzamide

HRID 1119141Notes

Reaction equation

HRID 1119141 reaction equation
[Br:1][c:2]1[n:3][cH:4][c:5](-[n:8]2[c:9]([C:19]([F:20])([F:21])[F:22])[n:10][c:11]3[c:12]2[cH:13][cH:14][c:15]([O:17][CH3:18])[cH:16]3)[n:6][cH:7]1.[CH2:45]1[O:46][CH2:47][CH2:48][O:49][CH2:50]1.[Cu:51][I:52].[F:23][c:24]1[cH:25][cH:26][c:27]([C:28](=[O:29])[NH2:30])[cH:31][cH:32]1.[K+:38].[K+:39].[K+:40].[NH2:41][CH2:42][CH2:43][NH2:44].[P:33]([O-:34])([O-:35])([O-:36])=[O:37]>>[c:2]1([NH:30][C:28]([c:27]2[cH:26][cH:25][c:24]([F:23])[cH:32][cH:31]2)=[O:29])[n:3][cH:4][c:5](-[n:8]2[c:9]([C:19]([F:20])([F:21])[F:22])[n:10][c:11]3[c:12]2[cH:13][cH:14][c:15]([O:17][CH3:18])[cH:16]3)[n:6][cH:7]1

Participants

8

Reactant 7

HCID 813Potassium Cation3×HCID 1061PhosphateHCID 3301EthylenediamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 312751,4-DioxaneHCID 715724-FluorobenzamideHCID 573569041-(5-Bromopyrazin-2-YL)-2-(trifluoromethyl)-5-methoxy-1H-benzo[D]imidazole

Product 1

HCID 589938444-Fluoro-N-[5-(5-methoxy-2-trifluoromethyl-benzoimidazol-1-yl)-pyrazin-2-yl]-benzamide

Sources & evidence

ORD record
ord-ee6ccd348542462c9b9f1045493a7141
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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