Hydrochloric Acid → 1,1-dimethylethyl (1RS,2RS)-2-(4-fluorophenyl)-2-hydroxy-1-((4-(trifluoromethyl)phenyl)methyl)ethylcarbamate

HRID 1119154Notes

Reaction equation

HRID 1119154 reaction equation
[CH3:34][OH:35].[ClH:36].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([CH2:21][c:22]3[cH:23][cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]3)[N:10]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[C:11](=[O:13])[O:12]2)[cH:6][cH:7]1.[Na+:33].[OH-:32].[OH2:37]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH:9]([NH:10][C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:21][c:22]2[cH:23][cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]2)[OH:12])[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 698294291,1-Dimethylethyl(4rs,5rs)-5-(4-fluorophenyl)-2-oxo-4-((4-(trifluoromethyl)phenyl)methyl)-1,3-oxazolidine-3-carboxylate

Product 1

HCID 865932161,1-dimethylethyl (1RS,2RS)-2-(4-fluorophenyl)-2-hydroxy-1-((4-(trifluoromethyl)phenyl)methyl)ethylcarbamate

Sources & evidence

ORD record
ord-abef588cfd8342fb8e00b76258c345f1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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