Tetrahydrofuran → Tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate

HRID 1119739Notes

Reaction equation

HRID 1119739 reaction equation
[C:1](#[CH:2])[c:3]1[c:4]([NH:11][C:12]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[c:5]([O:9][CH3:10])[cH:6][cH:7][cH:8]1.[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[CH3:24][O:25][N:26]([C:27](=[O:28])[c:29]1[cH:30][n:31][c:32]2[n:33]1[cH:34][cH:35][c:36]([O:38][CH2:39][CH2:40][O:41][CH3:42])[cH:37]2)[CH3:43].[Li:19][CH2:20][CH2:21][CH2:22][CH3:23]>>[C:1](#[C:2][C:27](=[O:28])[c:29]1[cH:30][n:31][c:32]2[n:33]1[cH:34][cH:35][c:36]([O:38][CH2:39][CH2:40][O:41][CH3:42])[cH:37]2)[c:3]1[c:4]([NH:11][C:12]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[c:5]([O:9][CH3:10])[cH:6][cH:7][cH:8]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 86638604Tert-butyl 2-ethynyl-6-methoxyphenylcarbamateHCID 86638605N-methoxy-7-(2-methoxyethoxy)-N-methylimidazo[1,2-a]pyridine-3-carboxamideHCID 178418339Butyllithium

Product 1

HCID 66781370Tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate

Sources & evidence

ORD record
ord-7649b1bd491541e28aaf7d186894d30c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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